Prevalence and Patterns of Renal Involvement Among Patients With Systemic Lupus Erythematous at a Tertiary Center.

BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by widespread inflammation and damage to multiple organ systems. One of the most common and severe manifestations of SLE is lupus nephritis (LN). OBJECTIVES: To determine the prevalence of LN among subjects with SLE and to identify the demographic, clinical, and laboratory parameters of SLE in subjects diagnosed with LN. METHODS: This is a descriptive study conducted at a tertiary hospital. Medical records were reviewed from outpatients who visited between January 2015 and October 2019 and who has fulfilled the classification criteria for diagnosis of SLE and had LN. RESULTS: Among 365 patients with SLE, 36% had LN. The most prevalent World Health Organization class of LN was IV, which significantly correlated with both abnormal creatinine levels and nephrotic range proteinuria. Elevated serum creatinine correlated with the presence of hypertension and thrombocytopenia. Cutaneous manifestations were noted to be present in 100% of LN patients, followed by arthritis and/or arthralgia (82.9%), anemia (94.6%), and lymphopenia (87.6%). CONCLUSION: This study aids in the recognition of the demographic, clinical, laboratory features, and the histological patterns of LN patients in Saudi Arabia, that probably has a role in the development and disease progression. A significant correlation was found between abnormal kidney function and hypertension, thrombocytopenia and nephrotic range proteinuria. The presence of World Health Organization class IV LN correlated with both impaired kidney function and nephrotic range proteinuria.

Hodgkin's Lymphoma in the Context of Psoriasis Vulgaris Treated With Immunosuppressive Therapy: A Case Report and Review of Literature.

Psoriasis is a multisystemic chronic inflammatory immune-mediated disorder presenting with multiple clinical manifestations and comorbidities. Studies suggested a significant association between the incidence of malignancy including Hodgkin's lymphoma and cutaneous T-cell lymphoma and malignancy-related deaths in patients with psoriasis owing to the disease itself, the chronic inflammation, and the immunosuppressive or immunomodulatory effect of drugs. This case report is discussing the condition of an 18-year-old female, who has developed Hodgkin's lymphoma after receiving immunosuppressive therapy in the context of psoriasis vulgaris flare-up.

Uterine Lipoleiomyoma: A Case Report and Review of Literature.

Uterine lipoleiomyoma is a rare benign neoplasm that falls under the umbrella of uterine leiomyoma. Upon histological examination, leiomyoma is primarily composed of smooth muscle cells of the uterus. Whereas, lipoleiomyoma reveals a characteristic pattern of mature adipocytes interspersed in uterine smooth muscles. This paper is discussing a case of a 60-year-old postmenopausal grand multiparous woman who presented with postmenopausal bleeding. A primary diagnosis of leiomyoma was made, however, histopathological diagnosis revealed its rare variant, lipoleiomyoma.

Dental Practitioners' Perception toward Management of Physically Challenged Patient among Saudi Arabia.

AIM AND OBJECTIVE: The aim of the current study is to evaluate the knowledge of dental practitioners in Saudi Arabia about managing physically challenged patients. MATERIALS AND METHODS: A cross-sectional digitalized survey was conducted among dental practitioners including both male and female. The questionnaire consisted of 20 items which included years of dental practice, previous experience treating a physically challenged patient, and any difficulties handling such cases. The survey was distributed through E-mail, social media official accounts. Chi-square test was used to investigate associations between factors using SPSS Pc+ version 22.0 statistical software package (Chicago, IL. WA). RESULTS: A total of 2030 dental practitioners participated in this study. The majority (91.0%) reported that their university was not good enough in preparing them to treat a physically challenged patient and they need to have more knowledge to treat them. Hearing impairment reported as the hardest to manage. Two-third (66.6%) reported that their clinic does not have the facilities to help in managing such patients. Statistically, a significant association was found between gender and most of the items of perception (P < 0.05). CONCLUSIONS: Treating physically challenged patients considered as a challenge for most of the dental practitioners in Saudi Arabia. Dental school should provide more courses and training programs about how to manage physically challenged patients. The use of communicating technology tools is highly recommended to manage those patients.